High-throughput Fabrication of Plasmonic Nanohole Array Sensors for Label-free Kinetic Biosensing

نویسندگان

  • Hyungsoon Im
  • Si Hoon Lee
  • Nathan J. Wittenberg
  • Timothy W. Johnson
  • Nathan C. Lindquist
  • Prashant Nagpal
  • David J. Norris
  • Sang-Hyun Oh
چکیده

In this work, we demonstrate high-throughput fabrication of periodic metallic nanohole arrays in an almost centimeter square area through simple metal deposition and peeling off processes, called template stripping [1]. A thin silica layer is used to protect the template-stripped Ag nanoholes from unwanted oxidation and also to provide a robust surface on which lipid membranes can be formed. We also demonstrate label-free optical biosensing of molecular binding kinetics with the silica coated template-stripped nanohole arrays.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Real-Time Label-Free Surface Plasmon Resonance Biosensing with Gold Nanohole Arrays Fabricated by Nanoimprint Lithography

In this work we present a surface plasmon resonance sensor based on enhanced optical transmission through sub-wavelength nanohole arrays. This technique is extremely sensitive to changes in the refractive index of the surrounding medium which result in a modulation of the transmitted light. The periodic gold nanohole array sensors were fabricated by high-throughput thermal nanoimprint lithograp...

متن کامل

Plasmonic Nanohole Arrays for Real-Time Multiplex Biosensing

Large-scale studies of biomolecular interactions required for proteome-level investigations can benefit from a new class of emerging surface plasmon resonance (SPR) sensors: nanohole arrays and surface plasmon (SP) enhanced optical transmission. In this paper we present a real-time, label-free multiplex SPR imaging sensor in a microarray format. The system presented is built around a low-cost m...

متن کامل

Optimized Design of Nanohole Array-Based Plasmonic Color Filters Integrating Genetic Algorithm with FDTD Solutions

Recently, significant interest has been attracted by the potential use of aluminum nanostructures as plasmonic color filters to be great alternatives to the commercial color filters based on dye films or pigments. These color filters offer potential applications in LCDs, LEDs, color printing, CMOS image sensors, and multispectral imaging. However, engineering the optical characteristics of thes...

متن کامل

Handheld high-throughput plasmonic biosensor using computational on-chip imaging

We demonstrate a handheld on-chip biosensing technology that employs plasmonic microarrays coupled with a lens-free computational imaging system towards multiplexed and high-throughput screening of biomolecular interactions for point-of-care applications and resource-limited settings. This lightweight and field-portable biosensing device, weighing 60 g and 7.5 cm tall, utilizes a compact optoel...

متن کامل

Lensfree optofluidic plasmonic sensor for real-time and label-free monitoring of molecular binding events over a wide field-of-view

We demonstrate a high-throughput biosensing device that utilizes microfluidics based plasmonic microarrays incorporated with dual-color on-chip imaging toward real-time and label-free monitoring of biomolecular interactions over a wide field-of-view of >20 mm(2). Weighing 40 grams with 8.8 cm in height, this biosensor utilizes an opto-electronic imager chip to record the diffraction patterns of...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2011